Development of a modified 3T3 Neutral Red Uptake Phototoxicity Test protocol for evaluation of poorly water-soluble substances
نویسندگان
چکیده
منابع مشابه
Nanosized Technological Approaches for the Delivery of Poorly Water Soluble Drugs
A major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. If the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. Although some approaches are available for enhancing th...
متن کاملCore-shell magnetic pH-responsive vehicle for delivery of poorly water-soluble rosuvastatin
Objective(s): Development of an oral sustained-controlled release vehicle which, slowly releases the drug and maintains an effective drug concentration for a long time is aimed.Materials and Methods: A biodegradable magnetic polymeric drug delivery vehicle, using superparamagnetic iron oxide nanoparticles encapsulating by polyvinylpyrrolidone-block-polyethylene glycol-block-poly methacrylic aci...
متن کاملa study on construction of iranian life tables: the case study of modified brass logit system
چکیده ندارد.
15 صفحه اولAppendix C Table of Contents 1.0 STANDARD OPERATING PROCEDURE (SOP) FOR THE BALB/C 3T3 NEUTRAL RED UPTAKE CYTOTOXICITY TEST - A TEST FOR BASAL
1.0 STANDARD OPERATING PROCEDURE (SOP) FOR THE BALB/C 3T3 NEUTRAL RED UPTAKE CYTOTOXICITY TEST A TEST FOR BASAL CYTOTOXICITY....................... 3 1.1 Background and Introduction.................................................................................................. 3 1.2 Rationale.........................................................................................................
متن کاملNanonization strategies for poorly water-soluble drugs.
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limita...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2017
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.42.569